Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

Acetyl coenzyme A (AcCoA) is the central biosynthetic precursor for fatty-acid synthesis and protein acetylation. In the conventional view of mammalian cell metabolism, AcCoA is primarily generated from glucose-derived pyruvate through the citrate shuttle and ATP citrate lyase in the cytosol. Howeve...

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Bibliographic Details
Main Authors: Metallo, Christian M., Gameiro, Paulo A., Bell, Eric L., Yang, Juanjuan, Hiller, Karsten, Jewell, Christopher M., Vander Heiden, Matthew G., Iliopoulos, Othon, Stephanopoulos, Gregory, Kelleher, Joanne Keene, Mattaini, Katherine Ruth, Guarente, Leonard Pershing, Johnson, Zachary, Irvine, Darrell J
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Nature Publishing Group 2014
Online Access:http://hdl.handle.net/1721.1/84489
https://orcid.org/0000-0002-6702-4192
https://orcid.org/0000-0003-0046-1360
https://orcid.org/0000-0002-8676-5738
https://orcid.org/0000-0003-4064-2510
https://orcid.org/0000-0001-6909-4568

Internet

http://hdl.handle.net/1721.1/84489
https://orcid.org/0000-0002-6702-4192
https://orcid.org/0000-0003-0046-1360
https://orcid.org/0000-0002-8676-5738
https://orcid.org/0000-0003-4064-2510
https://orcid.org/0000-0001-6909-4568

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