Sirtuin deacetylases in neurodegenerative diseases of aging

Sirtuin enzymes are a family of highly conserved protein deacetylases that depend on nicotinamide adenine dinucleotide (NAD+) for their activity. There are seven sirtuins in mammals and these proteins have been linked with caloric restriction and aging by modulating energy metabolism, genomic stabil...

Full description

Bibliographic Details
Main Authors: Herskovits, A. Zara, Guarente, Leonard Pershing
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Nature Publishing Group 2014
Online Access:http://hdl.handle.net/1721.1/84499
https://orcid.org/0000-0002-6841-4539
https://orcid.org/0000-0003-4064-2510