Sirtuin deacetylases in neurodegenerative diseases of aging
Sirtuin enzymes are a family of highly conserved protein deacetylases that depend on nicotinamide adenine dinucleotide (NAD+) for their activity. There are seven sirtuins in mammals and these proteins have been linked with caloric restriction and aging by modulating energy metabolism, genomic stabil...
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| Format: | Article |
| Language: | en_US |
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Nature Publishing Group
2014
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| Online Access: | http://hdl.handle.net/1721.1/84499 https://orcid.org/0000-0002-6841-4539 https://orcid.org/0000-0003-4064-2510 |
| _version_ | 1826205191141064704 |
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| author | Herskovits, A. Zara Guarente, Leonard Pershing |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Herskovits, A. Zara Guarente, Leonard Pershing |
| author_sort | Herskovits, A. Zara |
| collection | MIT |
| description | Sirtuin enzymes are a family of highly conserved protein deacetylases that depend on nicotinamide adenine dinucleotide (NAD+) for their activity. There are seven sirtuins in mammals and these proteins have been linked with caloric restriction and aging by modulating energy metabolism, genomic stability and stress resistance. Sirtuin enzymes are potential therapeutic targets in a variety of human diseases including cancer, diabetes, inflammatory disorders and neurodegenerative disease. Modulation of sirtuin activity has been shown to impact the course of several aggregate-forming neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis and spinal and bulbar muscular atrophy. Sirtuins can influence the progression of neurodegenerative disorders by modulating transcription factor activity and directly deacetylating proteotoxic species. Here, we describe sirtuin protein targets in several aggregate-forming neurodegenerative diseases and discuss the therapeutic potential of compounds that modulate sirtuin activity in these disorders. |
| first_indexed | 2024-09-23T13:08:48Z |
| format | Article |
| id | mit-1721.1/84499 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:08:48Z |
| publishDate | 2014 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/844992022-09-28T12:13:19Z Sirtuin deacetylases in neurodegenerative diseases of aging Herskovits, A. Zara Guarente, Leonard Pershing Massachusetts Institute of Technology. Department of Biology Herskovits, A. Zara Guarente, Leonard Pershing Sirtuin enzymes are a family of highly conserved protein deacetylases that depend on nicotinamide adenine dinucleotide (NAD+) for their activity. There are seven sirtuins in mammals and these proteins have been linked with caloric restriction and aging by modulating energy metabolism, genomic stability and stress resistance. Sirtuin enzymes are potential therapeutic targets in a variety of human diseases including cancer, diabetes, inflammatory disorders and neurodegenerative disease. Modulation of sirtuin activity has been shown to impact the course of several aggregate-forming neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis and spinal and bulbar muscular atrophy. Sirtuins can influence the progression of neurodegenerative disorders by modulating transcription factor activity and directly deacetylating proteotoxic species. Here, we describe sirtuin protein targets in several aggregate-forming neurodegenerative diseases and discuss the therapeutic potential of compounds that modulate sirtuin activity in these disorders. 2014-01-24T17:17:02Z 2014-01-24T17:17:02Z 2013-05 Article http://purl.org/eprint/type/JournalArticle 1001-0602 1748-7838 http://hdl.handle.net/1721.1/84499 Herskovits, Adrianna Z, and Leonard Guarente. “Sirtuin Deacetylases in Neurodegenerative Diseases of Aging.” Cell Research 23.6 (2013): 746–758. https://orcid.org/0000-0002-6841-4539 https://orcid.org/0000-0003-4064-2510 en_US http://dx.doi.org/10.1038/cr.2013.70 Cell Research Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License http://creativecommons.org/licenses/by-nc-nd/3.0/ application/pdf Nature Publishing Group Cell Research |
| spellingShingle | Herskovits, A. Zara Guarente, Leonard Pershing Sirtuin deacetylases in neurodegenerative diseases of aging |
| title | Sirtuin deacetylases in neurodegenerative diseases of aging |
| title_full | Sirtuin deacetylases in neurodegenerative diseases of aging |
| title_fullStr | Sirtuin deacetylases in neurodegenerative diseases of aging |
| title_full_unstemmed | Sirtuin deacetylases in neurodegenerative diseases of aging |
| title_short | Sirtuin deacetylases in neurodegenerative diseases of aging |
| title_sort | sirtuin deacetylases in neurodegenerative diseases of aging |
| url | http://hdl.handle.net/1721.1/84499 https://orcid.org/0000-0002-6841-4539 https://orcid.org/0000-0003-4064-2510 |
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