SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin

SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin

Mesenchymal stem cells (MSCs) are multi‐potent cells that can differentiate into osteoblasts, adipocytes, chondrocytes and myocytes. This potential declines with aging. We investigated whether the sirtuin SIRT1 had a function in MSCs by creating MSC specific SIRT1 knock‐out (MSCKO) mice. Aged MSCKO...

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Bibliographic Details
Main Authors: Simic, Petra, Zainabadi, Kayvan, Sykes, David B., Saez, Borja, Lotinun, Sutada, Baron, Roland, Scadden, David, Schipani, Ernestina, Bell, Eric L., Guarente, Leonard Pershing
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Wiley Blackwell 2014
Online Access:http://hdl.handle.net/1721.1/84504
https://orcid.org/0000-0003-4064-2510

Internet

http://hdl.handle.net/1721.1/84504
https://orcid.org/0000-0003-4064-2510

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