Calorie restriction and sirtuins revisited
Calorie or dietary restriction (CR) has attracted attention because it is the oldest and most robust way to extend rodent life span. The idea that the nutrient sensors, termed sirtuins, might mediate effects of CR was proposed 13 years ago and has been challenged in the intervening years. This revie...
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| Format: | Article |
| Language: | en_US |
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Cold Spring Harbor Laboratory Press
2014
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| Online Access: | http://hdl.handle.net/1721.1/84509 https://orcid.org/0000-0003-4064-2510 |
| _version_ | 1826213896630829056 |
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| author | Guarente, Leonard Pershing |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Guarente, Leonard Pershing |
| author_sort | Guarente, Leonard Pershing |
| collection | MIT |
| description | Calorie or dietary restriction (CR) has attracted attention because it is the oldest and most robust way to extend rodent life span. The idea that the nutrient sensors, termed sirtuins, might mediate effects of CR was proposed 13 years ago and has been challenged in the intervening years. This review addresses these challenges and draws from a great body of new data in the sirtuin field that shows a systematic redirection of mammalian physiology in response to diet by sirtuins. The prospects for drugs that can deliver at least a subset of the benefits of CR seems very real. |
| first_indexed | 2024-09-23T15:56:34Z |
| format | Article |
| id | mit-1721.1/84509 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:56:34Z |
| publishDate | 2014 |
| publisher | Cold Spring Harbor Laboratory Press |
| record_format | dspace |
| spelling | mit-1721.1/845092022-10-02T05:12:19Z Calorie restriction and sirtuins revisited Guarente, Leonard Pershing Massachusetts Institute of Technology. Department of Biology Paul F. Glenn Center for Biology of Aging Research (Massachusetts Institute of Technology) Guarente, Leonard Pershing Calorie or dietary restriction (CR) has attracted attention because it is the oldest and most robust way to extend rodent life span. The idea that the nutrient sensors, termed sirtuins, might mediate effects of CR was proposed 13 years ago and has been challenged in the intervening years. This review addresses these challenges and draws from a great body of new data in the sirtuin field that shows a systematic redirection of mammalian physiology in response to diet by sirtuins. The prospects for drugs that can deliver at least a subset of the benefits of CR seems very real. National Institutes of Health (U.S.) Paul F. Glenn Foundation 2014-01-24T18:27:51Z 2014-01-24T18:27:51Z 2013-10 Article http://purl.org/eprint/type/JournalArticle 0890-9369 1549-5477 http://hdl.handle.net/1721.1/84509 Guarente, L. “Calorie restriction and sirtuins revisited.” Genes & Development 27, no. 19 (October 10, 2013): 2072-2085. https://orcid.org/0000-0003-4064-2510 en_US http://dx.doi.org/10.1101/gad.227439.113 Genes & Development Creative Commons Attribution-Noncommercial 3.0 http://creativecommons.org/licenses/by-nc/3.0/ application/pdf Cold Spring Harbor Laboratory Press Cold Spring Harbor Laboratory Press |
| spellingShingle | Guarente, Leonard Pershing Calorie restriction and sirtuins revisited |
| title | Calorie restriction and sirtuins revisited |
| title_full | Calorie restriction and sirtuins revisited |
| title_fullStr | Calorie restriction and sirtuins revisited |
| title_full_unstemmed | Calorie restriction and sirtuins revisited |
| title_short | Calorie restriction and sirtuins revisited |
| title_sort | calorie restriction and sirtuins revisited |
| url | http://hdl.handle.net/1721.1/84509 https://orcid.org/0000-0003-4064-2510 |
| work_keys_str_mv | AT guarenteleonardpershing calorierestrictionandsirtuinsrevisited |