The ClpS Adaptor Mediates Staged Delivery of N-End Rule Substrates to the AAA+ ClpAP Protease

The ClpS Adaptor Mediates Staged Delivery of N-End Rule Substrates to the AAA+ ClpAP Protease

The ClpS adaptor delivers N-end rule substrates to ClpAP, an energy-dependent AAA+ protease, for degradation. How ClpS binds specific N-end residues is known in atomic detail and clarified here, but the delivery mechanism is poorly understood. We show that substrate binding is enhanced when ClpS bin...

Full description

Bibliographic Details
Main Authors: Hou, Jennifer Y., Grant, Robert A., Roman-Hernandez, Giselle, Baker, Tania
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier 2014
Online Access:http://hdl.handle.net/1721.1/84568
https://orcid.org/0000-0002-1719-5399

Internet

http://hdl.handle.net/1721.1/84568
https://orcid.org/0000-0002-1719-5399

Similar Items