Mec1 Is One of Multiple Kinases that Prime the Mcm2-7 Helicase for Phosphorylation by Cdc7

Mec1 Is One of Multiple Kinases that Prime the Mcm2-7 Helicase for Phosphorylation by Cdc7

Activation of the eukaryotic replicative DNA helicase, the Mcm2-7 complex, requires phosphorylation by Cdc7/Dbf4 (Dbf4-dependent kinase or DDK), which, in turn, depends on prior phosphorylation of Mcm2-7 by an unknown kinase (or kinases). We identified DDK phosphorylation sites on Mcm4 and Mcm6 and...

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Bibliographic Details
Main Authors: Randell, John C.W., Chan, Clara Sophia, Francis, Laura I., Heller, Ryan C., Bell, Stephen P., Galani, Kyriakitsa, Fan, Andy, 1976-
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier 2014
Online Access:http://hdl.handle.net/1721.1/84582
https://orcid.org/0000-0002-7852-4328
https://orcid.org/0000-0002-2876-610X

Internet

http://hdl.handle.net/1721.1/84582
https://orcid.org/0000-0002-7852-4328
https://orcid.org/0000-0002-2876-610X

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