A complex network of factors with overlapping affinities represses splicing through intronic elements

A complex network of factors with overlapping affinities represses splicing through intronic elements

To better understand splicing regulation, we used a cell-based screen to identify ten diverse motifs that inhibit splicing from introns. Motifs were validated in another human cell type and gene context, and their presence correlated with in vivo splicing changes. All motifs exhibited exonic splicin...

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Bibliographic Details
Main Authors: Wang, Yang, Xiao, Xinshu, Zhang, Jianming, Choudhury, Rajarshi, Li, Kai, Ma, Meng, Wang, Zefeng, Robertson, Alex De Jong, Burge, Christopher B
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program
Format: Article
Language:en_US
Published: Nature Publishing Group 2014
Online Access:http://hdl.handle.net/1721.1/84589

Internet

http://hdl.handle.net/1721.1/84589

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