Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system

Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system

Technologies allowing for specific regulation of endogenous genes are valuable for the study of gene functions and have great potential in therapeutics. We created the CRISPR-on system, a two-component transcriptional activator consisting of a nuclease-dead Cas9 (dCas9) protein fused with a transcri...

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Bibliographic Details
Main Authors: Wang, Haoyi, Yang, Hui, Shi, Linyu, Katz, Yarden, Theunissen, Thorold W, Rangarajan, Sudharshan, Jaenisch, Rudolf, Shivalila, Chikdu Shakti, Dadon, Daniel Benjamin, Cheng, Albert Wu
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program
Format: Article
Language:en_US
Published: Nature Publishing Group 2014
Online Access:http://hdl.handle.net/1721.1/84630
https://orcid.org/0000-0002-7256-3158
https://orcid.org/0000-0002-2905-0306

Internet

http://hdl.handle.net/1721.1/84630
https://orcid.org/0000-0002-7256-3158
https://orcid.org/0000-0002-2905-0306

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