Proapoptotic Function of the Retinoblastoma Tumor Suppressor Protein

Proapoptotic Function of the Retinoblastoma Tumor Suppressor Protein

The retinoblastoma protein (pRB) tumor suppressor blocks cell proliferation by repressing the E2F transcription factors. This inhibition is relieved through mitogen-induced phosphorylation of pRB, triggering E2F release and activation of cell-cycle genes. E2F1 can also activate proapoptotic genes in...

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Bibliographic Details
Main Authors: Ianari, Alessandra, Natale, Tiziana, Calo, Eliezer, Ferretti, Elisabetta, Alesse, Edoardo, Screpanti, Isabella, Haigis, Kevin M., Gulino, Alberto, Lees, Jacqueline
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier 2014
Online Access:http://hdl.handle.net/1721.1/84669
https://orcid.org/0000-0001-9451-2194

Internet

http://hdl.handle.net/1721.1/84669
https://orcid.org/0000-0001-9451-2194

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