Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples

Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples

Detection of somatic point substitutions is a key step in characterizing the cancer genome. However, existing methods typically miss low-allelic-fraction mutations that occur in only a subset of the sequenced cells owing to either tumor heterogeneity or contamination by normal cells. Here we present...

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Bibliographic Details
Main Authors: Cibulskis, Kristian, Sivachenko, Andrey, Jaffe, David B., Sougnez, Carrie, Gabriel, Stacey B., Meyerson, Matthew L., Getz, Gad, Lawrence, Michael S., Carter, Scott L., Lander, Eric Steven
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Nature Publishing Group 2014
Online Access:http://hdl.handle.net/1721.1/84673

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http://hdl.handle.net/1721.1/84673

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