Evolutionary Dynamics of Gene and Isoform Regulation in Mammalian Tissues

Most mammalian genes produce multiple distinct messenger RNAs through alternative splicing, but the extent of splicing conservation is not clear. To assess tissue-specific transcriptome variation across mammals, we sequenced complementary DNA from nine tissues from four mammals and one bird in biolo...

Full description

Bibliographic Details
Main Authors: Merkin, Jason Jay, Russell, Caitlin, Chen, Ping, Burge, Christopher B
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: American Association for the Advancement of Science (AAAS) 2014
Online Access:http://hdl.handle.net/1721.1/84699