Fundamental differences in endoreplication in mammals and Drosophila revealed by analysis of endocycling and endomitotic cells

Throughout the plant and animal kingdoms specific cell types become polyploid, increasing their DNA content to attain a large cell size. In mammals, megakaryocytes (MKs) become polyploid before fragmenting into platelets. The mammalian trophoblast giant cells (TGCs) exploit their size to form a barr...

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Bibliographic Details
Main Authors: Sher, Noa, Von Stetina, Jessica R., Bell, George W., Matsuura, Shinobu, Ravid, Katya, Orr-Weaver, Terry
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2014
Online Access:http://hdl.handle.net/1721.1/84944
https://orcid.org/0000-0002-7934-111X