Regulated ADAM17-dependent EGF family ligand release by substrate-selecting signaling pathways

Regulated ADAM17-dependent EGF family ligand release by substrate-selecting signaling pathways

Ectodomain cleavage of cell-surface proteins by A disintegrin and metalloproteinases (ADAMs) is highly regulated, and its dysregulation has been linked to many diseases. ADAM10 and ADAM17 cleave most disease-relevant substrates. Broad-spectrum metalloprotease inhibitors have failed clinically, and t...

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Bibliographic Details
Main Authors: Dang, Michelle, Armbruster, Nicole, Miller, Miles Aaron, Cermeno, Efrain A., Hartmann, Monika, Bell, George W., Root, David E., Herrlich, Andreas, Lauffenburger, Douglas A, Lodish, Harvey F
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2014
Online Access:http://hdl.handle.net/1721.1/84949
https://orcid.org/0000-0002-7029-7415

Internet

http://hdl.handle.net/1721.1/84949
https://orcid.org/0000-0002-7029-7415

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