Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles

Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles

Continuing efforts to discover novel means of combating fluconazole resistance in Candida albicans have identified an indole derivative that sensitizes strains demonstrating resistance to fluconazole. This tetracycle (3, ML229) does not appear to act through established Hsp90 or calcineurin pathways...

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Bibliographic Details
Main Authors: Youngsaye, Willmen, Dockendorff, Chris, Hartland, Cathy L., Bittker, Joshua A., Dandapani, Sivaraman, Palmer, Michelle, Whitesell, Luke, Lindquist, Susan, Schreiber, Stuart L., Munoz, Benito
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier B.V. 2014
Online Access:http://hdl.handle.net/1721.1/84955
https://orcid.org/0000-0003-1307-882X

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http://hdl.handle.net/1721.1/84955
https://orcid.org/0000-0003-1307-882X

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