The HCMV membrane glycoprotein US10 selectively targets HLA-G for degradation

Human cytomegalovirus (HCMV) encodes an endoplasmic reticulum (ER)-resident transmembrane glycoprotein, US10, expressed early in the replicative cycle of HCMV as part of the same cluster that encodes the known immunoevasins US2, US3, US6, and US11. We show that US10 down-regulates cell surface expre...

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Bibliographic Details
Main Authors: Park, Boyoun, Spooner, Eric, Houser, Brandy L., Strominger, Jack L., Ploegh, Hidde
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Rockefeller University Press, The 2014
Online Access:http://hdl.handle.net/1721.1/84990
https://orcid.org/0000-0002-1090-6071