Design of orthogonal genetic switches based on a crosstalk map of σs, anti-σs, and promoters

Design of orthogonal genetic switches based on a crosstalk map of σs, anti-σs, and promoters

Cells react to their environment through gene regulatory networks. Network integrity requires minimization of undesired crosstalk between their biomolecules. Similar constraints also limit the use of regulators when building synthetic circuits for engineering applications. Here, we mapped the promot...

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Bibliographic Details
Main Authors: Rhodius, Virgil A., Sharon, Brian D., Orlova, Ekaterina, Tabakh, Hannah, Burkhardt, David H., Clancy, Kevin, Peterson, Todd C., Gross, Carol A., Segall-Shapiro, Thomas H., Ghodasara, Amar Navin, Voigt, Christopher A.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Nature Publishing Group 2014
Online Access:http://hdl.handle.net/1721.1/84999
https://orcid.org/0000-0001-5409-1831
https://orcid.org/0000-0003-0844-4776
https://orcid.org/0000-0001-9364-6537

Internet

http://hdl.handle.net/1721.1/84999
https://orcid.org/0000-0001-5409-1831
https://orcid.org/0000-0003-0844-4776
https://orcid.org/0000-0001-9364-6537

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