Pten-Null Tumors Cohabiting the Same Lung Display Differential AKT Activation and Sensitivity to Dietary Restriction

Pten-Null Tumors Cohabiting the Same Lung Display Differential AKT Activation and Sensitivity to Dietary Restriction

PTEN loss is considered a biomarker for activated phosphoinositide 3-kinase (PI3K)/AKT, a pathway frequently mutated in cancer, and was recently shown to confer resistance to dietary restriction. Here, we show that Pten loss is not sufficient to drive AKT activation and resistance to dietary restric...

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Bibliographic Details
Main Authors: Curry, Natasha L., Mino-Kenudson, Mari, Oliver, Trudy, Yilmaz, Omer, Yilmaz, Vedat O., Moon, Jade Y., Jacks, Tyler E., Sabatini, David M., Kalaany, Nada Y.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: American Association for Cancer Research 2014
Online Access:http://hdl.handle.net/1721.1/85099
https://orcid.org/0000-0001-5785-8911
https://orcid.org/0000-0002-7577-4612
https://orcid.org/0000-0002-1446-7256

Internet

http://hdl.handle.net/1721.1/85099
https://orcid.org/0000-0001-5785-8911
https://orcid.org/0000-0002-7577-4612
https://orcid.org/0000-0002-1446-7256

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