Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells

Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells

Proliferating cells, including cancer cells, require altered metabolism to efficiently incorporate nutrients such as glucose into biomass. The M2 isoform of pyruvate kinase (PKM2) promotes the metabolism of glucose by aerobic glycolysis and contributes to anabolic metabolism. Paradoxically, decrease...

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Bibliographic Details
Main Authors: Vander Heiden, Matthew G., Locasale, Jason W., Swanson, Kenneth D., Sharfi, Hadar, Heffron, Gregory J., Amador-Noguez, Daniel, Christofk, Heather R., Wagner, Gerhard, Rabinowitz, Joshua D., Asara, John M., Cantley, Lewis C.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: American Association for the Advancement of Science 2014
Online Access:http://hdl.handle.net/1721.1/85108
https://orcid.org/0000-0002-6702-4192

Internet

http://hdl.handle.net/1721.1/85108
https://orcid.org/0000-0002-6702-4192

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