Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State

Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State

Decremental loss of PTEN results in cancer susceptibility and tumor progression. PTEN elevation might therefore be an attractive option for cancer prevention and therapy. We have generated several transgenic mouse lines with PTEN expression elevated to varying levels by taking advantage of bacterial...

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Bibliographic Details
Main Authors: Garcia-Cao, Isabel, Song, Min Sup, Hobbs, Robin M., Laurent, Gaelle, Giorgi, Carlotta, de Boer, Vincent C. J., Anastasiou, Dimitrios, Ito, Keisuke, Sasaki, Atsuo T., Rameh, Lucia, Carracedo, Arkaitz, Vander Heiden, Matthew G., Cantley, Lewis C., Pinton, Paolo, Haigis, Marcia C., Pandolfi, Pier Paolo, Vander Heiden, Matthew G.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier B.V. 2014
Online Access:http://hdl.handle.net/1721.1/85109
https://orcid.org/0000-0002-6702-4192

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http://hdl.handle.net/1721.1/85109
https://orcid.org/0000-0002-6702-4192

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