DHODH modulates transcriptional elongation in the neural crest and melanoma
Melanoma is a tumour of transformed melanocytes, which are originally derived from the embryonic neural crest. It is unknown to what extent the programs that regulate neural crest development interact with mutations in the BRAF oncogene, which is the most commonly mutated gene in human melanoma1. We...
Main Authors: | White, Richard Mark, Cech, Jennifer N., Ratanasirintrawoot, Sutheera, Lin, Charles Y., Rahl, Peter B., Burke, Christopher J., Langdon, Erin, Tomlinson, Matthew L., Mosher, Jack, Kaufman, Charles, Chen, Frank, Long, Hannah K., Kramer, Martin, Datta, Sumon, Neuberg, Donna S., Granter, Scott, Young, Richard A., Morrison, Sean, Wheeler, Grant N., Zon, Leonard I. |
---|---|
Other Authors: | Massachusetts Institute of Technology. Department of Biology |
Format: | Article |
Language: | en_US |
Published: |
Nature Publishing Group
2014
|
Online Access: | http://hdl.handle.net/1721.1/85176 https://orcid.org/0000-0001-8855-8647 |
Similar Items
-
Research Progress on Mechanism of Action of DHODH in Progression of Malignant Tumors
by: CHE Xin, et al.
Published: (2024-03-01) -
DHODH is an independent prognostic marker and potent therapeutic target in neuroblastoma
by: Thale Kristin Olsen, et al.
Published: (2022-10-01) -
The Warburg effect modulates DHODH role in ferroptosis: a review
by: Alvan Amos, et al.
Published: (2023-05-01) -
Targeting DHODH reveals therapeutic opportunities in ATRA-resistant acute promyelocytic leukemia
by: Tingyuan Yang, et al.
Published: (2023-10-01) -
Inhibition of DHODH Enhances Replication-Associated Genomic Instability and Promotes Sensitivity in Endometrial Cancer
by: Shengyuan Zhao, et al.
Published: (2023-12-01)