Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides Using Oxime-Based Diversification

Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides Using Oxime-Based Diversification

In an effort to develop improved binding antagonists of the polo-like kinase 1 (Plk1) polo-box domain (PBD), we optimized interactions of the known high affinity 5-mer peptide PLHSpT using oxime-based post solid-phase peptide diversification of the N-terminal Pro residue. This allowed us to achieve...

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Bibliographic Details
Main Authors: Liu, Fa, Park, Jung-Eun, Qian, Wen-Jian, Scharow, Andrej, Berg, Thorsten, Lee, Kyung S., Lim, Daniel Cham-Chin, Yaffe, Michael B, Burke, Terrence R.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: American Chemical Society (ACS) 2014
Online Access:http://hdl.handle.net/1721.1/85193
https://orcid.org/0000-0002-9547-3251

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http://hdl.handle.net/1721.1/85193
https://orcid.org/0000-0002-9547-3251

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