Hydroxyurea Induces Hydroxyl Radical-Mediated Cell Death in Escherichia coli

Hydroxyurea Induces Hydroxyl Radical-Mediated Cell Death in Escherichia coli

Hydroxyurea (HU) specifically inhibits class I ribonucleotide reductase (RNR), depleting dNTP pools and leading to replication fork arrest. Although HU inhibition of RNR is well recognized, the mechanism by which it leads to cell death remains unknown. To investigate the mechanism of HU-induced cell...

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Bibliographic Details
Main Authors: Davies, Bryan W., Kohanski, Michael A., Simmons, Lyle A., Winkler, Jonathan A., Collins, James J., Walker, Graham C.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier B.V. 2014
Online Access:http://hdl.handle.net/1721.1/85546
https://orcid.org/0000-0001-7243-8261

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http://hdl.handle.net/1721.1/85546
https://orcid.org/0000-0001-7243-8261

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