Promoter directionality is controlled by U1 snRNP and polyadenylation signals

Promoter directionality is controlled by U1 snRNP and polyadenylation signals

Transcription of the mammalian genome is pervasive, but productive transcription outside of protein-coding genes is limited by unknown mechanisms1. In particular, although RNA polymerase II (RNAPII) initiates divergently from most active gene promoters, productive elongation occurs primarily in the...

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Bibliographic Details
Main Authors: Almada, Albert Ernesto, Wu, Xuebing, Kriz, Andrea J., Sharp, Phillip A., Burge, Christopher B
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program
Format: Article
Language:en_US
Published: Nature Publishing Group 2014
Online Access:http://hdl.handle.net/1721.1/85556
https://orcid.org/0000-0003-1465-1691
https://orcid.org/0000-0003-0369-5269

Internet

http://hdl.handle.net/1721.1/85556
https://orcid.org/0000-0003-1465-1691
https://orcid.org/0000-0003-0369-5269

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