Promoter directionality is controlled by U1 snRNP and polyadenylation signals
Transcription of the mammalian genome is pervasive, but productive transcription outside of protein-coding genes is limited by unknown mechanisms1. In particular, although RNA polymerase II (RNAPII) initiates divergently from most active gene promoters, productive elongation occurs primarily in the...
Main Authors: | Almada, Albert Ernesto, Wu, Xuebing, Kriz, Andrea J., Sharp, Phillip A., Burge, Christopher B |
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Other Authors: | Massachusetts Institute of Technology. Computational and Systems Biology Program |
Format: | Article |
Language: | en_US |
Published: |
Nature Publishing Group
2014
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Online Access: | http://hdl.handle.net/1721.1/85556 https://orcid.org/0000-0003-1465-1691 https://orcid.org/0000-0003-0369-5269 |
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