Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts

Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts

MicroRNAs (miRNAs) are critical to proliferation, differentiation, and development. Here, we characterize gene expression in murine Dicer-null adult mesenchymal stem cell lines, a fibroblast cell type. Loss of Dicer leads to derepression of let-7 targets at levels that exceed 10-fold to 100-fold wit...

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Bibliographic Details
Main Authors: Gurtan, Allan M., Ravi, Arvind, Bosson, Andrew David, JnBaptiste, Courtney Kenneil, Bhutkar, Arjun (AJ), Whittaker, Charles A., Young, Richard A., Sharp, Phillip A., Rahl, Peter B.
Other Authors: Whitaker College of Health Sciences and Technology
Format: Article
Language:en_US
Published: Cold Spring Harbor Laboratory Press 2014
Online Access:http://hdl.handle.net/1721.1/85578
https://orcid.org/0000-0003-1465-1691
https://orcid.org/0000-0001-8855-8647
https://orcid.org/0000-0001-8353-9316

Internet

http://hdl.handle.net/1721.1/85578
https://orcid.org/0000-0003-1465-1691
https://orcid.org/0000-0001-8855-8647
https://orcid.org/0000-0001-8353-9316

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