Zanamivir Conjugated to Poly-L-Glutamine is Much More Active Against Influenza Viruses in Mice and Ferrets Than the Drug Itself

Zanamivir Conjugated to Poly-L-Glutamine is Much More Active Against Influenza Viruses in Mice and Ferrets Than the Drug Itself

Purpose: Previously, polymer-attached zanamivir had been found to inhibit influenza A viruses in vitro far better than did small-molecule zanamivir (1) itself. The aim of this study was to identify in vitro—using the plaque reduction assay—a highly potent 1-polymer conjugate, and subsequently test...

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Bibliographic Details
Main Authors: Belser, Jessica A., Tumpey, Terrence M., Chen, Jianzhu, Klibanov, Alexander M., Weight, Alisha Kessel
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Springer-Verlag 2014
Online Access:http://hdl.handle.net/1721.1/85586
https://orcid.org/0000-0003-3830-714X
https://orcid.org/0000-0002-5687-6154

Internet

http://hdl.handle.net/1721.1/85586
https://orcid.org/0000-0003-3830-714X
https://orcid.org/0000-0002-5687-6154

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