Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number

Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number

Genome-wide association studies (GWASs) have identified a genetic variant of moderate effect size at 6p21.1 associated with erythrocyte traits in humans. We show that this variant affects an erythroid-specific enhancer of CCND3. A Ccnd3 knockout mouse phenocopies these erythroid phenotypes, with a d...

Popoln opis

Bibliografske podrobnosti
Main Authors: Eng, Jennifer Christina, Sankaran, Vijay G., Ludwig, Leif S., Sicinska, Ewa, Xu, Jian, Bauer, Daniel E., Patterson, Heide Christine, Metcalf, Ryan A., Natkunam, Yasodha, Orkin, Stuart H., Sicinski, Piotr, Lander, Eric Steven, Lodish, Harvey F
Drugi avtorji: Massachusetts Institute of Technology. Department of Biology
Format: Article
Jezik:en_US
Izdano: Cold Spring Harbor Laboratory Press 2014
Online dostop:http://hdl.handle.net/1721.1/85590
https://orcid.org/0000-0002-7029-7415

Internet

http://hdl.handle.net/1721.1/85590
https://orcid.org/0000-0002-7029-7415

Podobne knjige/članki