Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

Rapamycin, an inhibitor of mechanistic target of rapamycin complex 1 (mTORC1), extends the life spans of yeast, flies, and mice. Calorie restriction, which increases life span and insulin sensitivity, is proposed to function by inhibition of mTORC1, yet paradoxically, chronic administration of rapam...

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Bibliographic Details
Main Authors: Lamming, Dudley W., Ye, Lan, Katajisto, Pekka, Goncalves, Marcus D., Saitoh, Maki, Stevens, Deanna M., Davis, James G., Salmon, Adam B., Richardson, Arlan, Ahima, Rexford S., Guertin, David A., Baur, Joseph A., Sabatini, David
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: American Association for the Advancement of Science 2014
Online Access:http://hdl.handle.net/1721.1/85837
https://orcid.org/0000-0002-0079-4467
https://orcid.org/0000-0002-1446-7256

Internet

http://hdl.handle.net/1721.1/85837
https://orcid.org/0000-0002-0079-4467
https://orcid.org/0000-0002-1446-7256

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