Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

Rapamycin, an inhibitor of mechanistic target of rapamycin complex 1 (mTORC1), extends the life spans of yeast, flies, and mice. Calorie restriction, which increases life span and insulin sensitivity, is proposed to function by inhibition of mTORC1, yet paradoxically, chronic administration of rapam...

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Detaylı Bibliyografya
Asıl Yazarlar: Lamming, Dudley W., Ye, Lan, Katajisto, Pekka, Goncalves, Marcus D., Saitoh, Maki, Stevens, Deanna M., Davis, James G., Salmon, Adam B., Richardson, Arlan, Ahima, Rexford S., Guertin, David A., Baur, Joseph A., Sabatini, David
Diğer Yazarlar: Massachusetts Institute of Technology. Department of Biology
Materyal Türü: Makale
Dil:en_US
Baskı/Yayın Bilgisi: American Association for the Advancement of Science 2014
Online Erişim:http://hdl.handle.net/1721.1/85837
https://orcid.org/0000-0002-0079-4467
https://orcid.org/0000-0002-1446-7256

Internet

http://hdl.handle.net/1721.1/85837
https://orcid.org/0000-0002-0079-4467
https://orcid.org/0000-0002-1446-7256

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