Alternative transcription start site selection leads to large differences in translation activity in yeast

mRNA levels do not accurately predict protein levels in eukaryotic cells. To investigate contributions of 5′ untranslated regions (5′ UTRs) to mRNA-specific differences in translation, we determined the 5′ UTR boundaries of 96 yeast genes for which in vivo translational efficiency varied by 80-fold....

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Bibliographic Details
Main Authors: Gilbert, Wendy, Rojas Duran, Maria Fernanda
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Cold Spring Harbor Laboratory Press 2014
Online Access:http://hdl.handle.net/1721.1/85841
https://orcid.org/0000-0003-2807-9657