Tumor suppressor gene Rb is required for self-renewal of spermatogonial stem cells in mice

The retinoblastoma tumor suppressor gene Rb is essential for maintaining the quiescence and for regulating the differentiation of somatic stem cells. Inactivation of Rb in somatic stem cells typically leads to their overexpansion, often followed by increased apoptosis, defective terminal differentia...

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Bibliographic Details
Main Authors: Hu, Yueh-Chiang, de Rooij, Dirk G., Page, David C
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2014
Online Access:http://hdl.handle.net/1721.1/85906
https://orcid.org/0000-0001-9920-3411