Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1

Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1

Reactive intermediates such as reactive nitrogen species play essential roles in the cell as signaling molecules but, in excess, constitute a major source of cellular damage. We found that nitrosative stress induced by steady-state nitric oxide (NO) caused rapid activation of an ATM damage-response...

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Bibliographic Details
Main Authors: Trudel, Laura J., Wogan, Gerald N., Tripathi, Durga N., Chowdhury, Rajdeep, Tee, Andrew R., Slack, Rebecca S., Walker, Cheryl Lyn
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2014
Online Access:http://hdl.handle.net/1721.1/85913
https://orcid.org/0000-0003-0771-9889

Internet

http://hdl.handle.net/1721.1/85913
https://orcid.org/0000-0003-0771-9889

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