Cytochrome P450 Drives a HIF-Regulated Behavioral Response to Reoxygenation by C. elegans

Oxygen deprivation followed by reoxygenation causes pathological responses in many disorders, including ischemic stroke, heart attacks, and reperfusion injury. Key aspects of ischemia-reperfusion can be modeled by a Caenorhabditis elegans behavior, the O2-ON response, which is suppressed by hypoxic...

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Bibliographic Details
Main Authors: Ma, Dengke, Zheng, Shu, Bhatla, Nikhil, Pender, Corinne Lenore, Rothe, Michael, Menzel, Ralph, Horvitz, Howard Robert
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: American Association for the Advancement of Science (AAAS) 2014
Online Access:http://hdl.handle.net/1721.1/85967
https://orcid.org/0000-0001-7092-3079
https://orcid.org/0000-0002-9964-9613
https://orcid.org/0000-0002-1693-4524