Caged Mono- and Divalent Ligands for Light-Assisted Disruption of PDZ Domain-Mediated Interactions

Caged Mono- and Divalent Ligands for Light-Assisted Disruption of PDZ Domain-Mediated Interactions

We report a general method for light-assisted control of interactions of PDZ domain binding motifs with their cognate domains by the incorporation of a photolabile caging group onto the essential C-terminal carboxylate binding determinant of the motif. The strategy was implemented and validated for...

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Bibliographic Details
Main Authors: Sainlos, Matthieu, Iskenderian, Wendy S., Olivier, Nelson B., Choquet, Daniel, Imperiali, Barbara
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: American Chemical Society 2014
Online Access:http://hdl.handle.net/1721.1/86182
https://orcid.org/0000-0002-3615-1789
https://orcid.org/0000-0002-5749-7869

Internet

http://hdl.handle.net/1721.1/86182
https://orcid.org/0000-0002-3615-1789
https://orcid.org/0000-0002-5749-7869

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