A beamforming approach to phase-amplitude modulation analysis of multi-channel EEG

Phase-amplitude modulation is a form of cross frequency coupling where the phase of one frequency influences the amplitude of another higher frequency. It has been observed in neurophysiological recordings during sensory, motor, and cognitive tasks, as well as during general anesthesia. In this pape...

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Bibliographic Details
Main Authors: Sampson, A. L., Mukamel, Eran A., Babadi, Behtash, Prerau, Michael J., Brown, Emery N., Purdon, Patrick Lee
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: Institute of Electrical and Electronics Engineers (IEEE) 2014
Online Access:http://hdl.handle.net/1721.1/86316
https://orcid.org/0000-0001-5651-5060
https://orcid.org/0000-0003-2668-7819
https://orcid.org/0000-0001-7955-9437
Description
Summary:Phase-amplitude modulation is a form of cross frequency coupling where the phase of one frequency influences the amplitude of another higher frequency. It has been observed in neurophysiological recordings during sensory, motor, and cognitive tasks, as well as during general anesthesia. In this paper, we describe a novel beamforming procedure to improve estimation of phase-amplitude modulation. We apply this method to 64-channel EEG data recorded during propofol general anesthesia. The method improves the sensitivity of phase-amplitude analyses, and can be applied to a variety of multi-channel neuroscience data where phase-amplitude modulation is present.