Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

Chromatin regulators have become attractive targets for cancer therapy, but it is unclear why inhibition of these ubiquitous regulators should have gene-specific effects in tumor cells. Here, we investigate how inhibition of the widely expressed transcriptional coactivator BRD4 leads to selective in...

Full description

Bibliographic Details
Main Authors: Loven, Jakob, Hoke, Heather Ashley, Lin, Charles Y., Lau, Ashley, Orlando, David A., Vakoc, Christopher R., Bradner, James E., Lee, Tong Ihn, Young, Richard A.
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program
Format: Article
Language:en_US
Published: Elsevier 2014
Online Access:http://hdl.handle.net/1721.1/86330
https://orcid.org/0000-0003-4549-5425
https://orcid.org/0000-0001-8855-8647

Internet

http://hdl.handle.net/1721.1/86330
https://orcid.org/0000-0003-4549-5425
https://orcid.org/0000-0001-8855-8647

Similar Items