Canine Hereditary Ataxia in Old English Sheepdogs and Gordon Setters Is Associated with a Defect in the Autophagy Gene Encoding RAB24

Canine Hereditary Ataxia in Old English Sheepdogs and Gordon Setters Is Associated with a Defect in the Autophagy Gene Encoding RAB24

Old English Sheepdogs and Gordon Setters suffer from a juvenile onset, autosomal recessive form of canine hereditary ataxia primarily affecting the Purkinje neuron of the cerebellar cortex. The clinical and histological characteristics are analogous to hereditary ataxias in humans. Linkage and genom...

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Bibliographic Details
Main Authors: Agler, Caryline, Nielsen, Dahlia M., Urkasemsin, Ganokon, Singleton, Andrew, Tonomura, Noriko, Sigurdsson, Snaevar, Tang, Ruqi, Linder, Keith, Arepalli, Sampath, Hernandez, Dena, Lindblad-Toh, Kerstin, van de Leemput, Joyce, Motsinger-Reif, Alison, O'Brien, Dennis P., Bell, Jerold, Harris, Tonya, Steinberg, Steven, Olby, Natasha J.
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:en_US
Published: Public Library of Science 2014
Online Access:http://hdl.handle.net/1721.1/86370

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http://hdl.handle.net/1721.1/86370

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