Long Signaling Cascades Tend to Attenuate Retroactivity

Signaling pathways consisting of phosphorylation/dephosphorylation cycles with no explicit feedback allow signals to propagate not only from upstream to downstream but also from downstream to upstream due to retroactivity at the interconnection between phosphorylation/dephosphorylation cycles. Howev...

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Bibliographic Details
Main Authors: Ossareh, Hamid R., Ventura, Alejandra C., Merajver, Sofia D., Del Vecchio, Domitilla
Other Authors: Massachusetts Institute of Technology. Department of Mechanical Engineering
Format: Article
Language:en_US
Published: Elsevier 2014
Online Access:http://hdl.handle.net/1721.1/86371
https://orcid.org/0000-0001-6472-8576