Twofold C−H Functionalization: Palladium-Catalyzed Ortho Arylation of Anilides

The ortho arylation of anilides to form biphenyls via a twofold C−H functionalization/C−C bond-forming process is described. The oxidative coupling takes place in the presence of 5−10 mol % of Pd(OAc)[subscript 2], 10−20 mol % of DMSO, and 4−11 equiv of the aryl substrate in TFA under an oxygen atmo...

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Bibliographic Details
Main Authors: Brasche, Gordon, Garcia-Fortanet, Jorge, Buchwald, Stephen Leffler
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:en_US
Published: American Chemical Society 2014
Online Access:http://hdl.handle.net/1721.1/87074
https://orcid.org/0000-0003-3875-4775