Twofold C−H Functionalization: Palladium-Catalyzed Ortho Arylation of Anilides
The ortho arylation of anilides to form biphenyls via a twofold C−H functionalization/C−C bond-forming process is described. The oxidative coupling takes place in the presence of 5−10 mol % of Pd(OAc)[subscript 2], 10−20 mol % of DMSO, and 4−11 equiv of the aryl substrate in TFA under an oxygen atmo...
Main Authors: | Brasche, Gordon, Garcia-Fortanet, Jorge, Buchwald, Stephen Leffler |
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Other Authors: | Massachusetts Institute of Technology. Department of Chemistry |
Format: | Article |
Language: | en_US |
Published: |
American Chemical Society
2014
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Online Access: | http://hdl.handle.net/1721.1/87074 https://orcid.org/0000-0003-3875-4775 |
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