Tissue-specific gene silencing monitored in circulating RNA

Tissue-specific gene silencing monitored in circulating RNA

Pharmacologic target gene modulation is the primary objective for RNA antagonist strategies and gene therapy. Here we show that mRNAs encoding tissue-specific gene transcripts can be detected in biological fluids and that RNAi-mediated target gene silencing in the liver and brain results in quantita...

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Bibliographic Details
Main Authors: Sehgal, Alfica, Chen, Qingmin, Gibbings, Derrick, Sah, Dinah W. Y., Bumcrot, David A.
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:en_US
Published: Cold Spring Harbor Laboratory Press 2014
Online Access:http://hdl.handle.net/1721.1/87563

Internet

http://hdl.handle.net/1721.1/87563

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