Myeloid-Specific Rictor Deletion Induces M1 Macrophage Polarization and Potentiates In Vivo Pro-Inflammatory Response to Lipopolysaccharide

Myeloid-Specific Rictor Deletion Induces M1 Macrophage Polarization and Potentiates In Vivo Pro-Inflammatory Response to Lipopolysaccharide

The phosphoinositide-3-kinase (PI3K)/protein kinase B (Akt) axis plays a central role in attenuating inflammation upon macrophage stimulation with toll-like receptor (TLR) ligands. The mechanistic target of rapamycin complex 2 (mTORC2) relays signal from PI3K to Akt but its role in modulating inflam...

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Bibliographic Details
Main Authors: Festuccia, William T., Pouliot, Philippe, Bakan, Inan, Sabatini, David M., Laplante, Mathieu
Other Authors: Whitehead Institute for Biomedical Research
Format: Article
Language:en_US
Published: Public Library of Science 2014
Online Access:http://hdl.handle.net/1721.1/88060
https://orcid.org/0000-0002-1446-7256

Internet

http://hdl.handle.net/1721.1/88060
https://orcid.org/0000-0002-1446-7256

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