Transcriptional silencing of γ-globin by BCL11A involves long-range interactions and cooperation with SOX6

Transcriptional silencing of γ-globin by BCL11A involves long-range interactions and cooperation with SOX6

The developmental switch from human fetal (γ) to adult (β) hemoglobin represents a clinically important example of developmental gene regulation. The transcription factor BCL11A is a central mediator of γ-globin silencing and hemoglobin switching. Here we determine chromatin occupancy of BCL11A at t...

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Bibliographic Details
Main Authors: Xu, Jian, Sankaran, Vijay G., Ni, Min, Menne, Tobias F., Puram, Rishi Venkata, Kim, Woojin, Orkin, Stuart H.
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: Cold Spring Harbor Laboratory Press 2014
Online Access:http://hdl.handle.net/1721.1/88498
https://orcid.org/0000-0002-7712-3231

Internet

http://hdl.handle.net/1721.1/88498
https://orcid.org/0000-0002-7712-3231

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