Reduction of Human Defensin 5 Affords a High-Affinity Zinc-Chelating Peptide

Reduction of Human Defensin 5 Affords a High-Affinity Zinc-Chelating Peptide

Human defensin 5 (HD5) is a 32-residue cysteine-rich host-defense peptide that exhibits three disulfide bonds in the oxidized form (HD5[subscript ox]). It is abundant in small intestinal Paneth cells, which release HD5 into the intestinal lumen and house a labile Zn(II) store of unknown function. He...

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Bibliographic Details
Main Authors: Zhang, Yunfei, Cougnon, Fabien, Wanniarachchi, Yoshitha A., Hayden, Joshua A., Nolan, Elizabeth M.
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:en_US
Published: American Chemical Society (ACS) 2014
Online Access:http://hdl.handle.net/1721.1/88524
https://orcid.org/0000-0002-6153-8803
https://orcid.org/0000-0002-6426-2291

Internet

http://hdl.handle.net/1721.1/88524
https://orcid.org/0000-0002-6153-8803
https://orcid.org/0000-0002-6426-2291

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