Benzannulation via the Reaction of Ynamides and Vinylketenes. Application to the Synthesis of Highly Substituted Indoles

A two-stage “tandem strategy” for the synthesis of indoles with a high level of substitution on the six-membered ring is described. Benzannulation based on the reaction of cyclobutenones with ynamides proceeds via a cascade of four pericyclic reactions to produce multiply substituted aniline derivat...

Full description

Bibliographic Details
Main Authors: Lam, Tin Yiu, Wang, Yu-Pu, Danheiser, Rick Lane
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:en_US
Published: American Chemical Society (ACS) 2014
Online Access:http://hdl.handle.net/1721.1/88725
https://orcid.org/0000-0002-9812-206X
https://orcid.org/0000-0001-5002-2230