In Situ Analysis of 8-Oxo-7,8-dihydro-2′-deoxyguanosine Oxidation Reveals Sequence- and Agent-Specific Damage Spectra

In Situ Analysis of 8-Oxo-7,8-dihydro-2′-deoxyguanosine Oxidation Reveals Sequence- and Agent-Specific Damage Spectra

Guanine is a major target for oxidation in DNA, with 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) as a major product. 8-oxodG is itself significantly more susceptible to oxidation than guanine, with the resulting damage consisting of more than 10 different products. This complexity has hampered eff...

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Bibliographic Details
Main Authors: Lim, Kok Seong, Cui, Liang, Taghizadeh, Koli, Wishnok, John S., Chan, Wan Simon, DeMott, Michael S., Babu, I. Ramesh, Dedon, Peter C., Tannenbaum, Steven Robert
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences
Format: Article
Language:en_US
Published: American Chemical Society (ACS) 2014
Online Access:http://hdl.handle.net/1721.1/88781
https://orcid.org/0000-0003-0011-3067
https://orcid.org/0000-0001-8533-2706
https://orcid.org/0000-0002-2325-552X
https://orcid.org/0000-0002-4607-5337

Internet

http://hdl.handle.net/1721.1/88781
https://orcid.org/0000-0003-0011-3067
https://orcid.org/0000-0001-8533-2706
https://orcid.org/0000-0002-2325-552X
https://orcid.org/0000-0002-4607-5337

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