Quantification of Cellular Poly(ADP-ribosyl)ation by Stable Isotope Dilution Mass Spectrometry Reveals Tissue- and Drug-Dependent Stress Response Dynamics

Quantification of Cellular Poly(ADP-ribosyl)ation by Stable Isotope Dilution Mass Spectrometry Reveals Tissue- and Drug-Dependent Stress Response Dynamics

Poly(ADP-ribosyl)ation is an essential post-translational modification with the biopolymer poly(ADP-ribose) (PAR). The reaction is catalyzed by poly(ADP-ribose) polymerases (PARPs) and plays key roles in cellular physiology and stress response. PARP inhibitors are currently being tested in clinical...

Full description

Bibliographic Details
Main Authors: Martello, Rita, Mangerich, Aswin, Sass, Sabine, Dedon, Peter C., Burkle, Alexander
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences
Format: Article
Language:en_US
Published: American Chemical Society (ACS) 2014
Online Access:http://hdl.handle.net/1721.1/88785
https://orcid.org/0000-0002-5811-6853
https://orcid.org/0000-0003-0011-3067

Internet

http://hdl.handle.net/1721.1/88785
https://orcid.org/0000-0002-5811-6853
https://orcid.org/0000-0003-0011-3067

Similar Items