Convergent synthesis of a steroidal antiestrogen-mitomycin C hybrid using “click” chemistry

Convergent synthesis of a steroidal antiestrogen-mitomycin C hybrid using “click” chemistry

A convergent synthesis of a novel estrogen receptor-targeted drug hybrid was developed based on structures of the potent anti-proliferative mitomycin C and the steroidal anti-estrogen RU 39411. The steroidal antiestrogen was prepared with an azido-triethylene glycoloxy linker while the mitomycin C d...

Full description

Bibliographic Details
Main Authors: Hanson, Robert N., Hua, Edward, Labaree, David, Hochberg, Richard B., Proffitt, Kyle, Essigmann, John M., Croy, Robert G.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Royal Society of Chemistry 2014
Online Access:http://hdl.handle.net/1721.1/88910
https://orcid.org/0000-0002-2196-5691

Internet

http://hdl.handle.net/1721.1/88910
https://orcid.org/0000-0002-2196-5691

Similar Items