In vitro models for liver toxicity testing

Over the years, various liver-derived in vitro model systems have been developed to enable investigation of the potential adverse effects of chemicals and drugs. Liver tissue slices, isolated microsomes, perfused liver, immortalized cell lines, and primary hepatocytes have been used extensively. Imm...

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Bibliographic Details
Main Authors: Soldatow, Valerie Y., LeCluyse, Edward L., Griffith, Linda G., Rusyn, Ivan
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Royal Society of Chemistry 2014
Online Access:http://hdl.handle.net/1721.1/88931
https://orcid.org/0000-0002-1801-5548