Structural Determinants for Naturally Evolving H5N1 Hemagglutinin to Switch Its Receptor Specificity

Structural Determinants for Naturally Evolving H5N1 Hemagglutinin to Switch Its Receptor Specificity

Of the factors governing human-to-human transmission of the highly pathogenic avian-adapted H5N1 virus, the most critical is the acquisition of mutations on the viral hemagglutinin (HA) to “quantitatively switch” its binding from avian to human glycan receptors. Here, we describe a structural framew...

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Bibliographic Details
Main Authors: Tharakaraman, Kannan, Raman, Rahul, Viswanathan, Karthik, Stebbins, Nathan W., Jayaraman, Akila, Krishnan, Arvind, Sasisekharan, Ram, Stebbins, Nathan W., Sasisekharan, Viswanathan
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Elsevier 2014
Online Access:http://hdl.handle.net/1721.1/89056
https://orcid.org/0000-0002-1288-9965
https://orcid.org/0000-0002-2085-7840
https://orcid.org/0000-0002-6528-0125

Internet

http://hdl.handle.net/1721.1/89056
https://orcid.org/0000-0002-1288-9965
https://orcid.org/0000-0002-2085-7840
https://orcid.org/0000-0002-6528-0125

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